Document Type
Student Paper
Publication Date
Spring 5-2022
Abstract
To develop a chromatographic method to characterize enantioselective kinetics, the reaction between aromatic aldehydes and ephedrine will be monitored with High Performance Liquid Chromatography (HPLC). First, develop kinetics analysis procedure with the HPLC, the decomposition of aspartame was observed with citrate and phosphate buffers. The procedure produced an activation energy in the presence of phosphate buffer of 71.9 kJ/mol with a -0.126 % error. The aromatic aldehyde, benzaldehyde, and ephedrine were run through a stereospecific column to separate peaks with various mobile phases. A more nonpolar mobile phase is required for better peak and retention time separation.
Recommended Citation
Overway, Ken and Shifflett, Mary Ruth, "High Performance Liquid Chromatography Monitoring Reaction Kinetics" (2022). Chemistry Faculty Scholarship. 14.
https://digitalcommons.bridgewater.edu/chemistry_faulty_scholarship/14