Document Type
Honors Project
First Advisor
Barnabas Otoo
Second Advisor
Stephen Baron
Third Advisor
Robyn Puffenbarger
Degree Award Date
Spring 5-4-2024
Keywords
α-Chloro-β-Lactone, DCC catalyst, DCU byproduct, Acid Work-up, Flash Chromatography
Disciplines
Medicinal-Pharmaceutical Chemistry | Organic Chemistry
Abstract
This research investigates the synthesis of α-chloro-β-lactone molecules, focusing on the production, isolation, and purification of two precursor compounds from chloroacetic acid and substituted benzaldehydes. While multiple methods were explored, including EDC, DIC, and DCC catalysis, DCC proved to be most effective in producing higher yields. However, challenges in purification arose due to the formation of byproducts, particularly with DCC, prompting further investigation for efficient extraction and purification techniques. DCC, however, shows a promising route for α-chloro-β-lactone synthesis, despite purification complexities.
Recommended Citation
Ellis, Matthew. “Purification and Isolation of α-Chloro-β-Lactone Precursor Molecules.” Senior Honors Projects, Bridgewater College, 2024.
Recommended Citation
Ellis, Matthew. “Purification and Isolation of α-Chloro-β-Lactone Precursor Molecules.” Senior Honors Projects, Bridgewater College, 2024.
Force Open Access
1