Document Type

Honors Project

First Advisor

Barnabas Otoo

Second Advisor

Stephen Baron

Third Advisor

Robyn Puffenbarger

Degree Award Date

Spring 5-4-2024


α-Chloro-β-Lactone, DCC catalyst, DCU byproduct, Acid Work-up, Flash Chromatography


Medicinal-Pharmaceutical Chemistry | Organic Chemistry


This research investigates the synthesis of α-chloro-β-lactone molecules, focusing on the production, isolation, and purification of two precursor compounds from chloroacetic acid and substituted benzaldehydes. While multiple methods were explored, including EDC, DIC, and DCC catalysis, DCC proved to be most effective in producing higher yields. However, challenges in purification arose due to the formation of byproducts, particularly with DCC, prompting further investigation for efficient extraction and purification techniques. DCC, however, shows a promising route for α-chloro-β-lactone synthesis, despite purification complexities.

Recommended Citation

Ellis, Matthew. “Purification and Isolation of α-Chloro-β-Lactone Precursor Molecules.” Senior Honors Projects, Bridgewater College, 2024.

Force Open Access