Document Type
Honors Project
Publication Date
Spring 2-15-2024
Abstract
This research investigates the synthesis of α-chloro-β-lactone molecules, focusing on the production, isolation, and purification of two precursor compounds from chloroacetic acid and substituted benzaldehydes. While multiple methods were explored, including EDC, DIC, and DCC catalysis, DCC proved to be most effective in producing higher yields. However, challenges in purification arose due to the formation of byproducts, particularly with DCC, prompting further investigation for efficient extraction and purification techniques. DCC, however, shows a promising route for α-chloro-β-lactone synthesis, despite purification complexities.
Recommended Citation
Ellis, Matthew. “Purification and Isolation of α-Chloro-β-Lactone Precursor Molecules.” Senior Honors Projects, Bridgewater College, 2024.
Included in
Medicinal-Pharmaceutical Chemistry Commons, Organic Chemicals Commons, Organic Chemistry Commons, Pharmaceutical Preparations Commons